A group of heroic firefighters at Seattle Fire Station 19—from captain to newest recruit—risk their lives and hearts both in the line of duty and off the clock. These brave men and women are like family, literally and figuratively, and together they put their own lives in jeopardy as first responders to save the lives of others.

What if a machine could tell you cryptically, but with 100% accuracy, how you are going to die?

Dr. Temperance Brennan and her colleagues at the Jeffersonian's Medico-Legal Lab assist Special Agent Seeley Booth with murder investigations when the remains are so badly decomposed, burned or destroyed that the standard identification methods are useless.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.