Set before the events of ‘Soul’, 22 refuses to go to Earth, enlisting a gang of 5 new souls in attempt of rebellion. However, 22’s subversive plot leads to a surprising revelation about the meaning of life.

Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.