With a heavy haul of 250 kilograms of gold bullion, the grizzled criminal mastermind, Rhino, and his ruthless gang of cutthroats, head to a ramshackle retreat somewhere in the Mediterranean to lay low on a scorching day of July. However, the unexpected and rather unwelcome arrival of the bohemian writer, Bernier, his muse, Luce, along with a pair of no-joke gendarmes further complicates things, as the frail allegiances will soon be put to the test.

A medical examiner discovers that an innocent shooting victim in a robbery died of bubonic plague. With only 48 hours to find the killer, who is now a ticking time bomb threatening the entire city, a grisly manhunt through the seamy underworld of the New Orleans Waterfront is underway.