Recently divorced entrepreneur George Lopez is successful in his business ventures but caught between two cultures in his personal life. He struggles to find balance between the parenting demands of his Anglo ex-wife, Mackenzie, and the cultural expectations of his Latina mother, Alma. His freeloading Uncle Tio and Cousin Junior further complicate his life, which includes 11-year-old son Harper. Outside the home, the successful businessman gives back to the community by teaching history to a multicultural class at a Los Angeles night school; there he is supervised by tough, attractive Assistant Principal Concepcion.

L.A.'s top Latino gang leader is release from jail on a technicality, swearing to kill both the cop who put him away and the priest who testified against him.

Bruce Nolan toils as a "human interest" television reporter in Buffalo, NY, but despite his high ratings and the love of his beautiful girlfriend, Bruce remains unfulfilled. At the end of the worst day in his life, he angrily ridicules God - and the Almighty responds, endowing Bruce with all of His divine powers.