Art student Paul Moon descends into the darkness of crystal meth with the help of his new-found dealer-philosopher Jay King.

4400 centers on the return of 4400 people who, previously presumed dead or reported missing, reappear on Earth. Though they have not aged physically, some of them seem to have deeper alterations ranging from superhuman strength to an unexplained healing touch. A government agency is formed to track the 4400 people after one of them commits a murder.