40 years in the future, space captain Ryan Clark and the crew of the luxury space cruise ship Avenue 5 navigate disgruntled passengers and unexpected events after experiencing technical difficulties onboard.

After fighting his demons for decades, John Rambo now lives in peace on his family ranch in Arizona, but his rest is interrupted when Gabriela, the granddaughter of his housekeeper María, disappears after crossing the border into Mexico to meet her biological father. Rambo, who has become a true father figure for Gabriela over the years, undertakes a desperate and dangerous journey to find her.

Ten years after the demise of Precrime, crime-solving is different and justice leans more on sophisticated and trusted technology than on the instincts of the precogs—individuals who able to see the future. In Washington, D.C., a man haunted by the future and a cop haunted by her past race to stop the worst crimes of the year 2065 before they happen.

A "contemporary prequel" to the 1960 film Psycho, depicting the life of Norman Bates and his mother Norma prior to the events portrayed in Hitchcock's film, albeit in a different fictional town and in a modern setting. The series begins after the death of Norma's husband, when she purchases a motel located in a coastal Oregon town so she and Norman can start a new life.