Englishman Adam and his American bride Sarah are about to embark on the romantic honeymoon of a lifetime in Venice, Italy. But when the newlyweds’ trip is gatecrashed by Adam’s excessively needy best friend, Ed, it inadvertently turns their perfect lovers’ holiday into a complete disaster.

In Rome it hasn’t rained for three years and the lack of water is overturning rules and habits. Through the city dying of thirst and prohibitions moves a chorus of people, young and old, marginalised and successful, victims and profiteers. Their lives are linked in a single design, while each seeks his or her deliverance.

In Rome, a Virgin Mary statue is found crying blood. Pondering on the implications of the existence of miracles, and eventually, the existence of God, the people involved in the enigma start losing their minds.