Twenty years after they were frozen, Abe, Cleo, JFK, and Joan suddenly find themselves thrust into the modern world, where they must navigate a fresh batch of historical clones, dramatic love triangles, and a formidable new foe.

A crime she committed in her youthful past sends Piper Chapman to a women's prison, where she trades her comfortable New York life for one of unexpected camaraderie and conflict in an eccentric group of fellow inmates.