Vampires kidnap the Sheriff and set off a war between vamps and humans to get control of San Gwynne Single Strain, the sweetest blood on Earth.

In a corrupt city, a small-time gangster and the estranged wife of a pot dealer find themselves thrown together in an escapade of love, money, drugs and danger.

Browning is a PI with a bad cold, who's sent to investigate a case by a mysterious client. He stumbles across the body of a young woman and is stabbed to death, and when he wakes up in heaven, they tell him he's "marginal material," and they can only decide on his final destination through one last assignment: to go back and solve his own murder. As a dog. A cute fluffy little dog (Benji). Undaunted, Browning begins to investigate the case as best he can around his canine disabilities (dialing the phone presents a special challenge) to solve the murders, save the girl, and see justice done.

After undergoing radical surgery for injuries from a motorcycle accident, a young woman develops a strange phallic growth on her body and a thirst for human blood—the only nourishment that will now sustain her.