After an unusual event, Zoey Clarke, a whip-smart computer coder forging her way in San Francisco, suddenly starts to hear the innermost wants, thoughts and desires of the people around her through popular songs.

Sweethearts Brad and Janet, stuck with a flat tire during a storm, discover the eerie mansion of Dr. Frank-N-Furter, a gender ambiguous scientist. As their innocence is lost, Brad and Janet meet a houseful of wild characters, including a rocking biker and a creepy butler. Through elaborate dances and rock songs, Frank-N-Furter unveils her latest creation: a muscular man named 'Rocky'.