A team of environmentalists, including a reporter, her camera man, and an environmentalist's famous girlfriend charter a boat and with the captain, sail to a military island. They suspect the island is hosting to illegal activities. Upon arrival, however, they find no one. They finally reach a deserted house, where they find Dr. Susan Richardson, who tells them that everyone on the island is dead, including her father. Richardson's team were working on a compound that could make edible plants grow to super size, however the military intervened with plans of their own. They wanted to test the compound's effects on animals, and proceeded to feed it to several komodo dragons and cobras.

CSI: Miami follows Crime Scene Investigators working for the Miami-Dade Police Department as they use physical evidence, similar to their Las Vegas counterparts, to solve grisly murders. The series mixes deduction, gritty subject matter, and character-driven drama in the same vein as the original series in the CSI franchise, except that the Miami CSIs are cops first, scientists second.