Mutant X is a science fiction television series that debuted on October 6, 2001. The show was created by Avi Arad, and it centers around Mutant X, a team of "New Mutants" who possess extraordinary powers as a result of genetic engineering. The members of Mutant X were used as test subjects in a series of covert government experiments. The mission of Mutant X is to seek out and protect their fellow New Mutants. The series was filmed in Toronto, Ontario, Canada. Even though the series had high ratings and was meant to be renewed for a fourth season, it was abruptly canceled in 2004 after the dismantling of Fireworks Entertainment, one of the show's production companies, ending the show on a cliffhanger.

Bested on the best-selling novel by author Robert B. Parker, Joe Mantegna is Spenser - Boston's best-known private eye. Called upon to investigate a case of murder, corruption, and betrayal, the super sleuth finds himself marked for death and on the run from a ruthless international assassin.