The series is set in New Gotham City, several years after it has been apparently abandoned by Batman. In his absence, Huntress, Oracle and Dinah are now the protectors of New Gotham: the Birds of Prey, and had taken over his war on crime. They are joined by Alfred Pennyworth, who serves Helena as she is heir to the Wayne estate; and Detective Jesse Reese, a police officer confronted with crimes and abilities he cannot explain. A central feature of the series is the concept of metahumans: individuals born with powers that cannot be explained. No two metahumans have the same abilities (unless hereditary), and there exists a whole subculture of metahuman society that the outside world knows nothing about.

Dan Merrick comes out from a shattering car accident with amnesia. He finds that he is married to Judith who is trying to help him start his life again. He keeps getting flashbacks about events and places that he can't remember. He meets pet shop owner and part time private detective Gus Klein who has supposedly done some work for him prior to the accident. Klein helps Merrick to find out more...