Explore the high-pressure experiences of police officers, paramedics and firefighters who are thrust into the most frightening, shocking and heart-stopping situations. These emergency responders must try to balance saving those who are at their most vulnerable with solving the problems in their own lives.

After a serial killer imitates the plots of his novels, successful mystery novelist Richard "Rick" Castle receives permission from the Mayor of New York City to tag along with an NYPD homicide investigation team for research purposes.

To improve its relations with Muslim countries, the United States government sends comedian Albert Brooks to south Asia to write a report on what makes followers of Islam laugh.

Workaholic Mike Flaherty is the Deputy Mayor of New York City, serving as Mayor Randall Winston's key strategist and much-needed handler. Mike runs the city with the help of his oddball staff: an anxious and insecure press secretary; a sexist, boorish chief of staff; an impeccably groomed gay activist running minority affairs; a sharp and efficient, man-crazy accountant; and an idealistic young speechwriter. Like Mike, they are all professionally capable but personally challenged.

Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household.