An underachieving college drop-out is dumped by his girlfriend of many years. Completely devastated, the young man employs his two best friends to aid him in an all night search through the New Jersey suburbs to find her. Closely following her trail, the trio encounter an evening of unpredictable adventure and bizarre mayhem they never bargained for.

Jerri Blank is a former prostitute and junkie whore who returns to high school as a 46-year-old freshman at Flatpoint High. Jerri ran away from home and became 'a boozer, a user, and a loser' after dropping out as a teenager, supporting her drug habits through prostitution, stripping, and larceny. She has been to prison several times, the last time because she 'stole the TV'. At home, Jerri's father Guy is comatose, although he seems perfectly capable of amazing feats. Her stepmother Sara is vain and bitter, and stepbrother Derrick is a bullying jock. Jerri tries to do things the right way but always ends up learning the wrong lesson. Her hijinks often involve, either directly or indirectly, neurotic history teacher Chuck Noblet and his secret lover, sensitive art teacher Geoffrey Jellineck.

Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household.