Lifelong friends Maddie, Helen and Dana Sue lift each other as they juggle relationships, family and careers in the small, Southern town of Serenity.

Marcus and Mike are forced to confront new threats, career changes, and midlife crises as they join the newly created elite team AMMO of the Miami police department to take down the ruthless Armando Armas, the vicious leader of a Miami drug cartel.

A workaholic hospital director is forced to re-examine her rigid lifestyle when a free-wheeling EMS pilot enters her life.

Two sets of adult siblings from wildly different worlds who discover they're related and must reassess everything they thought they knew about their shared father.