Ever since US Diplomatic Security Service Agent Hobbs and lawless outcast Shaw first faced off, they just have traded smack talk and body blows. But when cyber-genetically enhanced anarchist Brixton's ruthless actions threaten the future of humanity, they join forces to defeat him.

A bumbling young film crew, shooting a low-budget horror movie in an abandoned orphanage, discovers that a family of sadistic killers has rewritten their script.