Against the terrifying backdrop of a biological apocalypse, a Native teenager, Brian, comes out to his older sister, Faith, and homophobic brother, Charles. Conflict erupts among them as desperate survivors from the city seek refuge on the rez from the horrors of a 'megapox' epidemic that is quickly devastating urban populations across North America. Through a perilous journey to the city for food, where they rescue Brian's 'friend' in the process (an outrageous drag queen named Tonya), the hungry and frightened youth reach acceptance by facing down their fears.

Apples and Oranges is designed to raise children's awareness of the harmful effects of homophobia and gender-related name calling, intolerance, stereotyping and bullying. In the course of a lively in-class discussion among elementary students and an equity educator, children's paintings magically dissolve into two short animated stories. In Anta's Revenge, Anta finds out that creativity--not revenge--is the best way to deal with a school bully who makes fun of her for having two moms. Defying Gravity tells the story of Habib and Jeroux, two skateboarding friends whose relationship comes to a screeching halt when one of them finds out the other is gay.