Young sweethearts Billy and Kate move to the Big Apple, land jobs in a high-tech office park and soon reunite with the friendly and lovable Gizmo. But a series of accidents creates a whole new generation of Gremlins. The situation worsens when the devilish green creatures invade a top-secret laboratory and develop genetically altered powers, making them even harder to destroy!

Widowed pediatrician Harry Weston is a miracle worker when it comes to dealing with his young patients, but he's more challenged by the other people surrounding him: daughters Barbara and Carol; his wisecracking office assistant, nurse LaVerne Todd; and obnoxious neighborhood mooch Charley Dietz. Thank goodness he always finds a friendly shoulder (and a warm, wet tongue) in Dreyfuss, his enormous dog.