Lorelei Lee is a beautiful showgirl engaged to be married to the wealthy Gus Esmond, much to the disapproval of Gus' rich father, Esmond Sr., who thinks that Lorelei is just after his money. When Lorelei goes on a cruise accompanied only by her best friend, Dorothy Shaw, Esmond Sr. hires Ernie Malone, a private detective, to follow her and report any questionable behavior that would disqualify her from the marriage.

Advertising executive Alan Miller, a recovered alcoholic who now does interventions on behalf of Alcoholics Anonymous, is called to help Broadway actress Jenny Carey whose developing career is threatened by an increasing dependence on alcohol. Alan's growing interest in Jenny strains his marriage to Edna, with whom he has two children.

Pinky, a light skinned black woman, returns to her grandmother's house in the South after graduating from a Northern nursing school. Pinky tells her grandmother that she has been "passing" for white while at school in the North. In addition, she has fallen in love with a young white doctor, who knows nothing about her black heritage.