The ultimate disaster film parody. A nuclear-powered bus is making its maiden non-stop trip from New York to Denver. The journey is plagued by disasters due to the machinations of a mysterious group allied with the oil lobby. Will the down-on-his-luck driver, with a reputation for eating his passengers, be able to complete the journey?

A dishonest businessman asks rich layabout Craig Blake to help him buy a gym, which will be demolished for a development project in Alabama. But after spending time with weightlifter Joe Santo and gym worker Mary Tate Farnsworth, Craig wants out of the deal. The property negotiations turn ugly, causing a brawl at the gym and a spectacle at a big bodybuilding meet, as Craig learns that it's not easy to turn your back on fair-weather friends.

The story of Delancey Street Foundation, a self-help group devoted to reclaiming ex-junkies, ex-convicts, and others.

In the midst of the Depression, a crotchety doctor, whose practice is in the Brooklyn slums, takes an interest in a local teenager, whose hostility and erratic behavior the doctor believes is due to more than just his environment.