Harvard symbologist Robert Langdon is recruited by the Vatican to investigate the apparent return of the Illuminati - a secret, underground organization - after four cardinals are kidnapped on the night of the papal conclave.

In this sequel, Lillian has been adopted and it's several years later. Annie, married and pregnant, visits her fellow doctor friend, Dr. Owen. Dr Owen desperately wants a baby, but seems unable to become pregnant. Lillian finds a love interest, an assistant to her adoptive dad, the latter has become quite overprotective.