There's something in them woods and it's killin' hunters. On his bachelor party deer killin', beer drinkin', huntin' trip weekend; Randy's world is turned inside out. All's he wanted to do was to spend a lil' time with the fellers.

Mad scientist Prospero runs away with his blind daughter Miranda to Tromaville, hiding from evil pharmaceutical execs, including his own sister Antoinette who ruined his career after he found the cure against opioid addiction. With the help of a handicapped crack-whore, he releases a massive amount of laxative to whales, while his enemies are on a cruise ship to North Korea. A humongous shitstorm washes the boat away and brings them to Tromaville, where Prospero can now fully realize his ultimate vengeance.

A young punk named DOOD manifests his most self-deprecating thoughts in the form of a furry, devil-tongued flesh ball, then must discover how to get rid of the creature before it convinces him to get rid of himself.