Mad scientist Prospero runs away with his blind daughter Miranda to Tromaville, hiding from evil pharmaceutical execs, including his own sister Antoinette who ruined his career after he found the cure against opioid addiction. With the help of a handicapped crack-whore, he releases a massive amount of laxative to whales, while his enemies are on a cruise ship to North Korea. A humongous shitstorm washes the boat away and brings them to Tromaville, where Prospero can now fully realize his ultimate vengeance.

A pizza boy unknowingly goes a house off from his delivery and finds himself captured to be used as a sacrifice for a basement cult's God. In a battle of bloody carnage, the pizza boy must escape if he is to ever deliver another Italian pie again.