Regularly working alone undercover with a vice squad boss she dislikes as much as he dislikes her, Lottie Mason is living pretty much on the edge. An assignment helping out the Assistant D.A. may be the start of a serious relationship but then, tired and disillusioned after a job one night, she finds herself accepting a proposition in a bar that leads rapidly into a web of murder and deceit.

Ray Tango and Gabriel Cash are narcotics detectives who, while both being extremely successful, can't stand each other. Crime Lord Yves Perret, furious at the loss of income that Tango and Cash have caused him, frames the two for murder. Caught with the murder weapon on the scene of the crime, the two have no alibi. Thrown into prison with most of the criminals they helped convict, it appears that they are going to have to trust each other if they are to clear their names and catch the evil Perret.

A cop from Los Angeles travels to Miami to seek revenge against Cuban drug runners who killed his friend.