Lupe, an innocent young Mexican woman in LA, works two jobs to support her terminally-ill mother when she meets Benny, a handsome but troubled young man who draws her into a scheme to solve their money problems.

Ray Tango and Gabriel Cash are narcotics detectives who, while both being extremely successful, can't stand each other. Crime Lord Yves Perret, furious at the loss of income that Tango and Cash have caused him, frames the two for murder. Caught with the murder weapon on the scene of the crime, the two have no alibi. Thrown into prison with most of the criminals they helped convict, it appears that they are going to have to trust each other if they are to clear their names and catch the evil Perret.

A high-class call girl accused of murder fights for the right to stand trial rather than be declared mentally incompetent.