Ray Tango and Gabriel Cash are narcotics detectives who, while both being extremely successful, can't stand each other. Crime Lord Yves Perret, furious at the loss of income that Tango and Cash have caused him, frames the two for murder. Caught with the murder weapon on the scene of the crime, the two have no alibi. Thrown into prison with most of the criminals they helped convict, it appears that they are going to have to trust each other if they are to clear their names and catch the evil Perret.

A girl is killed and raped minutes after fighting with her boyfriend (Jeff) and he left her. Jeff is the assistant of professor Caldwell at the university, and he wanted to return with his old girlfriend (Lisa). The girl lived with another five girls, including Lisa. All these girls begin to be killed, one by one, in different and strange ways. The main suspect is Jeff.