A successful physician and devoted family man, John Dolittle seems to have the world by the tail, until a long suppressed talent he possessed as a child, the ability to communicate with animals is suddenly reawakened with a vengeance! Now every creature within squawking distance wants the good doctor's advice, unleashing an outrageous chain of events that turns his world upside down!

Madeline is married to Ernest, who was once arch-rival Helen's fiance. After recovering from a mental breakdown, Helen vows to kill Madeline and steal back Ernest. Unfortunately for everyone, the introduction of a magic potion causes things to be a great deal more complicated than a mere murder plot.

Columbo is a friendly, verbose, disheveled-looking police detective who is consistently underestimated by his suspects. Despite his unprepossessing appearance and apparent absentmindedness, he shrewdly solves all of his cases and secures all evidence needed for indictment. His formidable eye for detail and meticulously dedicated approach often become clear to the killer only late in the storyline.