Jules Cobb is a mom in her forties facing the often humorous challenges, pitfalls and rewards of life's next chapter. Along for the journey is her son, her ex-husband, her husband/neighbor and her friends who together make up her dysfunctional, but supportive and caring extended family... even if they have a funny way of showing it sometimes.

Bobby Gomez gets invited to a quinceañera by default, but when he can't find a tuxedo large enough, he's forced to wear his father's from 1972 which turns out to be a blessing in disguise.

Mick St. John is a captivating, charming and immortal private investigator from Los Angeles, who defies the traditional blood-sucking norms of his vampire tendencies by using his wit and powerful supernatural abilities to help the living.

Mexican immigrant and single mother Flor Moreno finds housekeeping work with Deborah and John Clasky, a well-off couple with two children of their own. When Flor admits she can't handle the schedule because of her daughter, Cristina, Deborah decides they should move into the Clasky home. Cultures clash and tensions run high as Flor and the Claskys struggle to share space while raising their children on their own, and very different, terms.

The whacky adventures of Ned Bigby and his best pals Moze and Cookie at James K. Polk Middle School, as "every-kid" Ned shatters the fourth wall to share tips and tricks on navigating middle school or junior high hurdles. Ned's not super cool, and he has no superpowers. He is, however, witty, well-groomed, upbeat and self-aware. Moreover, with more than a little help from his two best friends, he's equipped to conquer middle school minefields. From crushing bullies to crushes, from off- the-wall, mean and cool teachers to pop quizzes, elections and detentions, Ned knows that nothing, including the seventh grade, is as bad as it seems, and friendship matters most.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.