In this musical comedy, a pregnant disc jockey misses her husband who is fighting overseas. Stressed out by the situation and her job, she decides to take some time off and convinces her twin sister to trade places with her. The switcheroo causes the soldier her husband appointed as her unofficial guardian no end of confusion.

San Antonio Rose is an amiably wacky mini-musical evenly divided between its "official" stars, The Merry Macs, and a strong cast of supporting clowns. Robert Paige plays roadhouse operator Con Conway, whose establishment is in danger of being squeezed out by its competition. Stranded entertainers Hope Holloway (Jane Frazee) and Gabby Trent (Eve Arden) decide to revivify Conway's establishment by staging an energetic floor show built around the talented Merry Macs. A rival club owner dispatches his two top hooligans Jigsaw Kennedy (Lon Chaney Jr.) and Benny the Bounce (Shemp Howard) to wreck Conway's club by posing as waiters, but the two stupes are easily cowed into submission--by the leading ladies!