Dr. Peyton Westlake is on the verge of realizing a major breakthrough in synthetic skin when his laboratory is destroyed by gangsters. Having been burned beyond recognition and forever altered by an experimental medical procedure, Westlake becomes known as Darkman, assuming alternate identities in his quest for revenge and a new life with a former love.

Fed up of his business partner, Ernest Trend hires the services of two exterminators. When things go drastically wrong and they murder the wrong man, the race is on to frame an innocent video surveillance man.