Before their eventual team-up with Scooby and the gang, bright and optimistic Daphne and whip-smart and analytical Velma are both mystery-solving teens who are best friends but have only met online - until now. Daphne has just transferred to Velma's school, Ridge Valley High, an incredible tech-savvy institute with all the latest gadgets provided by the school's benefactor, tech billionaire Tobias Bloom. And while competition is fierce among the students for a coveted internship at Bloom Innovative, Daphne and Velma dig beyond all the gadgets and tech to investigate what is causing some of the brightest students in school to disappear - only to emerge again in a zombie-fied state.

Chet & Laura, a songwriting duo in their tenth year of trying to make it, start to realize their chances of success may have already passed them by.