The TARDIS arrives on Earth in July, 1966, on a runway at Gatwick Airport. Polly witnesses a murder in a nearby hangar and is then kidnapped by the perpetrator, Spencer of Chameleon Tours. Ben also vanishes. The Second Doctor and Jamie are left to convince the sceptical airport Commandant there has been foul play.

The TARDIS materialises in Paris in the year 1572 and the Doctor decides to visit the famous apothecary Charles Preslin. Steven, meanwhile, is befriended by a group of Huguenots from the household of the Protestant Admiral de Coligny. Having rescued a young serving girl, Anne Chaplet, from some pursuing guards, the Huguenots gain their first inkling of a heinous plan being hatched at the command of the Catholic Queen Mother, Catherine de Medici.