Harry Caine, a blind writer, reaches this moment in time when he has to heal his wounds from 14 years back. He was then still known by his real name, Mateo Blanco, and directing his last movie.

Basilio a pickpocket with no luck, enters a mental institution to retrieve a valuable diamond necklace that briefly passed through his hands and whose value was unable to recognize. Once inside the asylum, Basilio will try to use all the skills of his trade to overcome the threats that keep him from reaching his goal. In the end, the only escape for Basilio will be to undergo the "Torapia", an innovative experimental therapy that connects man with the beast within us all.

The story revolves around a Basque Roman Catholic priest dedicated to committing as many sins as possible, a death metal salesman from Carabanchel, and the Italian host of a TV show on the occult. These go on a literal "trip" through Christmas-time Madrid to hunt for and prevent the reincarnation of the Antichrist.