Arriving in the town of Tombstone, the First Doctor finds himself involved with gunmen out to kill Doc Holliday...

The TARDIS arrives in a desolate future London, where the Doctor discovers his old enemies the Daleks have taken control of Earth.

The Doctor, Ian, Barbara and Susan arrive in the TARDIS on board a spaceship. Their initial concern is for the ship's human crew, who are suffering from telepathic interference from the Sensorites, but Susan communicates with the Sensorites and finds the aliens fear an attack by the humans and are just defending themselves. Travelling to the Sense Sphere (the Sensorites' planet) the Doctor seeks to cure an illness to which the Sensorites and Ian have succumbed, but finds it has been caused by deliberate poisoning. The political manoeuvring of the Sensorite City Administrator poses another threat to the TARDIS crew as he seeks to discredit and implicate them.

The adventures of The Doctor, a time-traveling humanoid alien known as a Time Lord. He explores the universe in his TARDIS, a sentient time-traveling spaceship. Its exterior appears as a blue British police box, which was a common sight in Britain in 1963 when the series first aired. Along with a succession of companions, The Doctor faces a variety of foes while working to save civilizations, help ordinary people, and right many wrongs.