Struggling stand-up Sam Slade and reclusive writer Becky Holt are thrown together when Becky experiences strange phenomena in her own home, and Sam, desperately broke, poses as a private eye - but will Sam's first case be the death of her?

Billy is the self-designated leader of a group of teenagers living in a shelter. Jacob and Rae, Billy's oldest childhood friends, live there as well as part of "the family". Billy has an AIDs-like virus, which he has passed on to his blood brother Jacob. Billy and Rae are boyfriend and girlfriend, much to the dismay of Jacob who has always loved Rae from afar. Billy's philosophy of life, and how that interfaces with having a deadly virus, comes to a head when Billy and Jacob compete in a very unique game of "Tag", with the future of Rae and "the family" dependent upon the outcome.

The Time of Our Lives follows the lives of the extended Tivolli family as they navigate their way around relationships, raising kids, love, careers, divorce, disability and finding happiness. Elder brother Matt is a high-flying sports agent struggling with his obsessive wife Caroline. Younger brother Luce runs a much more relaxed household with long-time partner Bernadette, despite a chaotic schedule and financial pressures. Chai Li, the youngest, was adopted from Vietnam as a baby and is a successful and happy thirty-something until her world is shattered by a humiliating turn of events. Herb has known the family since childhood.

Sherlock Holmes and Watson are on the trail of a criminal and scientific mastermind who seems to control monsters and creations which defy belief.