The owner of a professional football team must restore the titular train and run it from Tennessee to NYC in 24 hours if he is to inherit $1 million in this comedy.

Scientist Dr. Bradford Crane and army general Thalius Slater join forces to fight an almost invisible enemy threatening America; killer bees that have deadly venom and attack without reason. Disaster movie-master Irwin Allen's film contains spectacular special effects, including a train crash caused by the eponymous swarm.