The Daleks draft the Second Doctor into distilling the Human Factor. Once implanted, it will make the Dalek race invincible. Jamie's faith in the Doctor is stretched to the limit as the Doctor appears to be collaborating with the Daleks. The Doctor has a few tricks up his sleeve, but then again so might the Daleks.

The Doctor, Ian, Barbara and Susan arrive in the TARDIS on board a spaceship. Their initial concern is for the ship's human crew, who are suffering from telepathic interference from the Sensorites, but Susan communicates with the Sensorites and finds the aliens fear an attack by the humans and are just defending themselves. Travelling to the Sense Sphere (the Sensorites' planet) the Doctor seeks to cure an illness to which the Sensorites and Ian have succumbed, but finds it has been caused by deliberate poisoning. The political manoeuvring of the Sensorite City Administrator poses another threat to the TARDIS crew as he seeks to discredit and implicate them.