A Heffley family road trip to attend Meemaw's 90th birthday party goes hilariously off course thanks to Greg's newest scheme to get to a video gaming convention.

Jackson's unhealthy eating habits lead to persistent nagging by his lady friend, which triggers Jackson to break off the relationship. Tony picks up the health baton and starts pressuring Jackson to take care of his body, emphasizing to him that the body is the temple of the Holy Spirit and that he cannot serve God with all his heart if his heart and other organs are laboring to fight off self induced toxin poisoning. Jackson takes sides in the ongoing battle for the right of people to choose their own medical treatment. He partners up with Tony and Julie to become a champion for those underdogs who fight against Big Pharma and the Monsantos of the world who reap a fortune as they seize power to run the lives of the little people and jeopardize the future of the planet in their attempt to misuse science and political science to usurp God.

Matthew was born with a silver spoon in his mouth that allows him to obtain his degree in theology from Harvard and land a sweet and lucrative pastoral gig that gives him freedom to recreate to his heart’s content. His new $74,000 Cadillac, which he dubs “White Lightning” is the pride of his considerable possessions. Matthew is also proud of his very upscale church in Tennessee. When God sends him a dream in the night, he has to reconsider his priorities in life. The nocturnal vision leads him to a local faith based drug/alcohol rehab center operated by Mission Teens. While Matthew is trying to determine a road map for his life, two substance abusers in the Heartland are trying to avoid being sent to an obscure community in Tennessee for rehabilitation. Circumstances put both Shane and Susan on the same bus, headed to Davy Crockett country and a rendezvous with a proud young pastor, Cupid, and the Holy Spirit