A dejected young photographer, turned low level drug peddler, bites off more than he can chew when his customer goes missing and he is left to look after the man's audacious sister days before the world is set to end.

A former professional dancer, Brooke, and her brother Cary, an aspiring actor, try to find their place in the world while wrestling with their feelings about their 13-year-old brother Chase's sudden rise to internet fame.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

Meanwhile concerns Joe Fulton, a man who can do anything from fixing your sink to arranging international financing for a construction project. He produces online advertising and he’s written a big fat novel. He’s also a pretty good drummer. But success eludes him. For Joe can’t keep himself from fixing other people’s problems. His own ambitions are constantly interrupted by his willingness and ability to go out of his way for others.

A misfit brother and sister try to salvage their broken lives by searching the country for the father they never knew.