'Pleasantly plump' teenager Tracy Turnblad achieves her dream of becoming a regular on the Corny Collins Dance Show. Now a teen hero, she starts using her fame to speak out for the causes she believes in, most of all integration. In doing so, she earns the wrath of the show's former star, Amber Von Tussle, as well as Amber's manipulative, pro-segregation parents. The rivalry comes to a head as Amber and Tracy vie for the title of Miss Auto Show 1963.

Blessed with a keen sense of smell and cursed with a philandering pornographer husband, a parasitic mother, and a pair of delinquent children, the long-suffering Francine Fishpaw turns to the bottle as her life falls apart -- until deliverance appears in the form of a hunk named Todd Tomorrow.

Notorious Baltimore criminal and underground figure Divine goes up against Connie & Raymond Marble, a sleazy married couple who make a passionate attempt to humiliate her and seize her tabloid-given title as "The Filthiest Person Alive".