Milan, Italy, now. Ray is at his favorite bar, where he waits for his friends, Scarpa and Il Divo. Ray is celebrating his 70th birthday, but the bartender – as anyone else in the world – does not care at all. Scarpa and Il Divo – both 70 years old – arrive. They have a special present for Ray. And a plan. The present is a gun, the plan is to go to Rome and achieve something epic, something everybody will talk about.

Geronimo Stilton is about the titular character, a mouse journalist and head of the Geronimo Stilton Media Group. He searches New Mouse City and places around the world for new scoops while having adventures along the way with his nephew Benjamin, cousin Trap, sister Thea and Benjamin's friend Pandora Woz. Most episodes share no story connections and are generally self-contained, though some episodes feature ties and characters from others.

The Minister of the Interior gets stuck in his ultra-technological car and a rival Member of Parliament tries desperately to help him, while chaos spreads around them.