Cherry drifts from college dropout to army medic in Iraq - anchored only by his true love, Emily. But after returning from the war with PTSD, his life spirals into drugs and crime as he struggles to find his place in the world.

After serving a prison term for her boyfriend, a streetwise, middle-aged moll named Gloria stands up against the mobs, which is complicated by a six-year-old urchin with a will of his own, whom she reluctantly takes under her wing after his family has been gunned down.

The lives of many individuals connected by the desire for happiness, often from sources usually considered dark or evil.

A man plans a perfect murder to get a lung transplant for his dying wife.

Workaholic Mike Flaherty is the Deputy Mayor of New York City, serving as Mayor Randall Winston's key strategist and much-needed handler. Mike runs the city with the help of his oddball staff: an anxious and insecure press secretary; a sexist, boorish chief of staff; an impeccably groomed gay activist running minority affairs; a sharp and efficient, man-crazy accountant; and an idealistic young speechwriter. Like Mike, they are all professionally capable but personally challenged.

On Christmas Eve, a relentlessly cheerful woman escapes from the killers hired by her husband, and embarks on a series of strange encounters.

Angel celebrates the birth of his daughter by taking his first hit of crack cocaine. With the hesitant support of his wife, Monika, he joins a friend of his to deal drugs for a short time--enough time to get out of debt and buy some nice things for the family. Three years later, Angel is still dealing, and has not saved any money, instead spending it on crack. His addiction grows, straining his friendship and his family life, and he gradually loses control.

In cases ripped from the headlines, police investigate serious and often deadly crimes, weighing the evidence and questioning the suspects until someone is taken into custody. The district attorney's office then builds a case to convict the perpetrator by proving the person guilty beyond a reasonable doubt. Working together, these expert teams navigate all sides of the complex criminal justice system to make New York a safer place.