Doofenshmirtz's latest "-inator" accidentally turns the citizens of Danville into contagious mindless repulsive pharmacists that look like him who run rampant all over town. Agent P and the kids must work together to save Danville and avoid becoming mindless repulsive pharmacists themselves.

An American girl, Daphne, heads to Europe in search of the father she's never met. But instead of finding a British version of her bohemian mother, she learns the love of her mom's life is an uptight politician. The only problem now is that her long-lost dad is engaged to a fiercely territorial social climber with a daughter who makes Daphne's life miserable.