Lou and Esther are the best of friends. They do absolutely everything together, speak their own language through inside jokes and code words, and share a dreamy curiosity about what their lives would be like had they grown up with a sister. When Lou’s father unexpectedly passes away, she discovers that she has a very real, and very chic, long-lost half-sister, Priya. As Lou begins to explore her relationship with Priya, her and Esther’s codependent bliss is rudely interrupted, creating a rift between them. As the rift threatens to grow beyond repair, Lou must learn to redefine what family is, or risk losing Esther for good.

In 2013, there are no highways, no I-ways, no dreams of a better tomorrow, only scattered survivors across what was once the Unites States. Into this apocalyptic wasteland comes an enigmatic drifter with a mule, a knack for Shakespeare, and something yet undiscovered: the power to inspire hope.

Ray Barone is a successful sportswriter living on Long Island with his wife Debra, daughter Ally, and twin sons, Geoffrey and Michael. That's the good news. The bad news? Ray's meddling parents, Frank and Marie, live directly across the street and embrace the motto "Su casa es mi casa," infiltrating their son's home to an extent unparalleled in television history.