Detectives Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force are tasked with stopping the flow of the drug ecstasy into Miami. They track the drugs to the whacked-out Cuban drug lord Johnny Tapia, who is also involved in a bloody war with Russian and Haitian mobsters. If that isn't bad enough, there's tension between the two detectives when Marcus discovers that playboy Mike is secretly romancing Marcus’ sister, Syd.

Sheena's parents were archaeologists who died in the jungle when she was about six years old, leaving their daughter Shirley Hamilton. She was taken in by Kali, a local Shamaness of a tribe who brought her up, and five years ago she was taught how to morph into animals and birds, acquiring their abilities, even flight. Further, she became a mythical creature called "The Darachna" who relies on people' fear of the unknown. For this she covers herself in a dark liquid mud which allows her to be largely unseen in the low light of the jungle, and with more than normal strength, agility and speed, and armed with a pair of gloves with bone claws, she is a formidable one woman fighting force. She does kill sometimes.

Clay Doyle, a drifter haunted by the ability to see violent events from the past, wanders into a small Florida town and falls in love with the ethereal Sarah Miller, despite increasingly disturbing visions of murder and decay.

Set in Chicago, the show follows the kid-friendly misadventures of two high-school friends who are always scheming and dreaming. Kenan, who works at a grocery store, constantly devises crazy plans to strike it rich, while orange-soda-loving buddy Kel is always dragged along for the ride despite his track record for messing things up.