William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.

Beautiful, intelligent, soulful Essence (Jillian Reeves) is a teacher and spoken word poet. Her open communication and passion for life is shared by Maurice (Lamman Rucker), a handsome and socially conscious teacher at a school for the deaf. Although their relationship is fairly new, they can feel their sexual chemistry growing. The two decide to move to the "next level" when the issue of HIV testing raises a new level of discussion. Will Essence and Maurice be able to sustain their relationship or are they simply on two different pages? Will this fire fizzle or continue to burn? "Let's Talk" explores issues concerning sex, safety and loving ourselves.

At home and school, she's Miley Stewart, a typical teenager, but when the lights go down and the curtain goes up, she emerges as the glamorous and talented Hannah Montana. Having the "Best of Both Worlds" is a complicated proposition, and keeping her identity under wraps leads Miley and her friends into some hilarious capers as she tries to balance her normal life with her rock star persona.

Follows the personal and professional lives of a group of doctors at Seattle’s Grey Sloan Memorial Hospital.