Cesare Proietti is the esteemed manager of the Relais Colombo, a luxury hotel in Milan. When a group of new Chinese business partners want to revolutionize everything, the hotel owner's daughter, Luciana, decides to fire Cesare. When Cesare discovers Luciana is looking for a caregiver who can look after her father, he decides to dress up as a charming woman to apply for the role.

Italian police inspector Coliandro — an ignorant, boorish, but fundamentally kind-hearted oaf, whose entire worldview is informed by American cop movies — protects the good citizens of Bologna, routinely saving the day and foiling the plans of evildoers of all sorts by a combination of dumb luck and genuine bravery, while always falling hopelessly in love with the woman at the center of the case.