A down-on-his-luck bookie befriends an ex-girlfriend’s son and gets the bright idea to take bets on his youth league baseball games; only to realize he’s killed what’s pure about the sport as the games turn ugly when money is on the line.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.