Ray Barone is a successful sportswriter living on Long Island with his wife Debra, daughter Ally, and twin sons, Geoffrey and Michael. That's the good news. The bad news? Ray's meddling parents, Frank and Marie, live directly across the street and embrace the motto "Su casa es mi casa," infiltrating their son's home to an extent unparalleled in television history.

An extraordinarily intelligent young girl from a cruel and uncaring family discovers she possesses telekinetic powers and is sent off to a school headed by a tyrannical principal.